Metabolic formation of nucleoside-modified analogues of S-adenosylmethionine |
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| Authors: | T P Zimmerman R D Deeprose G Wolberg G S Duncan |
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| Affiliation: | 1. Department of Cell Biology Laboratory at Baylor College of Medicine, Houston, Texas, 77030 USA;2. Howard Hughes Medical Institute Laboratory at Baylor College of Medicine, Houston, Texas, 77030 USA |
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| Abstract: | A Pseudo-ovalbumin gene, bearing significant nucleotide sequence homology to the ovalbumin gene, has been cloned from genomic chick DNA. Similar to the authentic ovalbumin gene, the pseudo-gene is a unique sequence gene in the chick genome and is expressed at a low level in the immature chick oviduct. In contrast to the ovalbumin gene, expression of the pseudo-gene in the oviduct is not inducible by estrogen. The concentration of pseudo-gene RNA is only ～0.01% of that of authentic ovalbumin mRNA in estrogen-stimulated oviduct cells. Nucleotide sequence analysis of the two sequence related genes may reveal the molecular basis of differential response to steroid hormone induction in the same tissue. |
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| Keywords: | AdoMet S-adenosylmethionine AdoHcy S-adenosylhomocysteine 7-deazaadenosine S-7-deazaadenosylmethionine COMT catechol-O-methyltransferase (EC 2.1.1.6) 3′-dAdo 3′-deoxyadenosine 3′-dAdoMet S-3′-deoxyadenosylmethionine EHNA FAdo 2-fluoroadenosine FAdoMet S-2-fluoroadenosylmethionine For formycin A ForMet S-formycinylmethionine HPLC high-performance liquid chromatography Neb nebularine NebMet S-nebularylmethionine 8-azaadenosine S-8-azaadenosylmethionine |
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