Proteasome activation delays aging in vitro and in vivo |
| |
Affiliation: | 1. Laboratório de Bioquímica e Biofísica, Instituto Butantan, São Paulo, SP, Brazil;2. Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil |
| |
Abstract: | Aging is a natural biological process that is characterized by a progressive accumulation of macromolecular damage. In the proteome, aging is accompanied by decreased protein homeostasis and function of the major cellular proteolytic systems, leading to the accumulation of unfolded, misfolded, or aggregated proteins. In particular, the proteasome is responsible for the removal of normal as well as damaged or misfolded proteins. Extensive work during the past several years has clearly demonstrated that proteasome activation by either genetic means or use of compounds significantly retards aging. Importantly, this represents a common feature across evolution, thereby suggesting proteasome activation to be an evolutionarily conserved mechanism of aging and longevity regulation. This review article reports on the means of function of these proteasome activators and how they regulate aging in various species. |
| |
Keywords: | Ubiquitin–proteasome system Proteasome activation Aging Senescence Longevity regulation Free radicals |
本文献已被 ScienceDirect 等数据库收录! |
|