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Mitochondrial thioredoxin reductase inhibition,selenium status,and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds
Affiliation:1. Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal;2. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden;1. Postgraduate Program in Biochemistry, Universidade Federal do Pampa, Uruguaiana, RS, Brazil;2. Department of Basic Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain;3. Bioactivity and Food Analysis Laboratory, Instituto de Investigación en Ciencias de la Alimentación, Madrid, Spain;4. Department of Physiological Sciences, Universidade Federal do Espírito Santo, Vitória, ES, Brazil;5. Department of Pharmacology, Universidad Autónoma de Madrid, Madrid, Spain;1. Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama, Japan;2. Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;3. Department of Development and Environmental Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan;1. Department of Chemistry and Materials Science, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, 21007 Huelva, Spain;2. Research Center on Health and Environment (CYSMA), University of Huelva, Spain;3. International Campus of Excellence on Agrofood (ceiA3), University of Huelva, Spain;4. Department of Environmental Biology and Public Health, Cell Biology, Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, 21007 Huelva, Spain
Abstract:
Keywords:Thioredoxin  Thioredoxin reductase  Mercury  Methylmercury  Selenium  mRNA  Nrf-2  Mitochondria  Free radicals
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