Intronic motif pairs cooperate across exons to promote pre-mRNA splicing |
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Authors: | Shengdong Ke Lawrence A Chasin |
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Institution: | (1) Department of Biological Sciences, Columbia University, 1212 Amsterdam Ave, MC 2433, New York, NY 10027, USA |
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Abstract: | Background A very early step in splice site recognition is exon definition, a process that is as yet poorly understood. Communication
between the two ends of an exon is thought to be required for this step. We report genome-wide evidence for exons being defined
through the combinatorial activity of motifs located in flanking intronic regions. |
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Keywords: | |
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