Vertebrate Hedgehog signaling: cilia rule |
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Authors: | Christopher W Wilson Didier YR Stainier |
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Affiliation: | (1) Tumour Biology and Angiogenesis Department, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA;(2) Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology, the Liver Center, Cardiovascular Research Institute and Diabetes Center, University of California, San Francisco, CA 94158, USA |
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Abstract: | The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction. |
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