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Vertebrate Hedgehog signaling: cilia rule
Authors:Christopher W Wilson  Didier YR Stainier
Affiliation:(1) Tumour Biology and Angiogenesis Department, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA;(2) Department of Biochemistry and Biophysics, Program in Developmental and Stem Cell Biology, the Liver Center, Cardiovascular Research Institute and Diabetes Center, University of California, San Francisco, CA 94158, USA
Abstract:The Hedgehog (Hh) signaling pathway differentially utilizes the primary cilium in mammals and fruit flies. Recent work, including a study in BMC Biology, demonstrates that Hh signals through the cilium in zebrafish, clarifying the evolution of Hh signal transduction.
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