Reversal of the surface effects of chlorhexidine diacetate on cells of Providencia stuartii |
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Authors: | N. Ismaeel J. R. Furr A. D. Russell |
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Affiliation: | Pharmaceutical Microbiology Research Laboratory, Welsh School of Pharmacy, University of Wales Institute of Science and Technology, PO Box 13, Cardiff CF1 3XF, UK |
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Abstract: | Chlorhexidine diacetate (CHA) increased the hydrophobicity of the cell surface of cells of three strains of Providencia stuartii. Removal of at least some of the CHA from the cells by washing them with an appropriate antidote partially reversed the hydrophobicity-increasing action of the biguanide. The effects of other treatments on cell surface hydrophobicity were examined with these strains and, for comparison, with two strains each of Escherichia coli and Pseudomonas aeruginosa: ethyl-enediamine tetraacetic acid affected all strains, although not to the same extent, whereas thermal injury (55°C) produced marked changes only with the two E. coli strains. |
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