Polymeric hemoglobins of the house mouse (Mus musculus L.): Isolation of cysteinyl peptides

Hemoglobins from wild populations of the house mouse (Mus musculus L.) are polymorphic with respect to the diffuse or single appearance of their electrophoretic patterns and their ability to form polymers. Polymerization occurs by the formation of intermolecular disulfide bonds. Isolation of all the cysteinyl peptides shows that the reactive cysteinyl residue, 13, is in the same position as that found in BALB/cJ laboratory mice.This research was supported in part by grant F-213 from the Robert A. Welch Foundation, and NIH grants GM-05818 and GM-09326, and an NIH predoctoral fellowship to J. B.