Chemical Constituents from the Heartwood of Haematoxylon campechianum as Protein Tyrosine Kinase Inhibitors |
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| Authors: | Li‐Gen Lin Hua Xie Yi‐Tao Wang Jian Ding Yang Ye |
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| Institution: | 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu‐Chong‐Zhi Road, Zhangjiang Hi‐tech Park, Shanghai 201203, P.?R. China;2. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira, Taipa, Macao, P.?R. China, (phone: +853‐83974873;3. fax: +853‐28841358) |
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| Abstract: | In a previous study, we showed that a series of homoisoflavonoids from the stems of Haematoxylon campechianum possess potent protein tyrosine kinase inhibitory activity. In a further chemical investigation of the heartwood of H. campechianum, three new homoisoflavonoids, epihematoxylol B ( 2 ), 10‐O‐methylhematoxylol B ( 3 ), and 10‐O‐methylepihematoxylol B ( 4 ), were isolated and identified, together with 15 known compounds, including three homoisoflavonoids, three flavonoids, six lignans, and three unsaturated fatty acids. The structures of the new compounds were established on the basis of 1D‐ and 2D‐NMR and other spectroscopic analyses. |
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| Keywords: | Haematoxylon campechianum Protein tyrosine kinases (PTKs) Epihematoxylol B Homoisoflavonoids Hematoxylol B 10‐O‐methyl‐ Kinase insert domain receptor (KDR) |
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