Antifungal Bromophenols from Marine Red Alga Symphyocladia latiuscula |
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| Authors: | Xiuli Xu Liyuan Yin Junhai Gao Lijie Gao Fuhang Song |
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| Affiliation: | 1. School of Ocean Sciences, China University of Geosciences, No.?29 Xueyuan Road, Haidian District, Beijing, 100083, P.?R. China, (phone: +86‐10‐82319124;2. fax: +86‐10‐82320065);3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, No.?1 Beichen West Road, Chaoyang District, Beijing 100101, P.?R. China, (phone: +86‐10‐64806058;4. fax: +86‐10‐64806058) |
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| Abstract: | Three new highly brominated polyphenols, 1 – 3 , together with one known bromophenol, 4 , were isolated from the EtOH extract of a marine red alga Symphyocladia latiuscula collected from the coast of Qingdao, P. R. China. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data. Compounds 3 and 4 showed activities against the Candida albicans with the MIC values of 25 and 12.5 μg/ml, respectively. |
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| Keywords: | Symphyocladia latiuscula Polyphenols, brominated Antifungal activity Candida albicans |
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