StructureOdor Relationships of Semisynthetic β‐Santalol Analogs |
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| Authors: | Céline Delasalle Claire A de March Uwe J Meierhenrich Hugues Brevard Jérôme Golebiowski Nicolas Baldovini |
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| Institution: | 1. Institute of Chemistry – Nice, University of Nice Sophia Antipolis, CNRS UMR 7272, Parc Valrose, FR‐06108 Nice (phone: +33492076133;2. fax: +33492076125);3. Robertet S.A., 37, avenue Sidi Brahim, B.P. 52100, FR‐06131 Grasse |
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| Abstract: | A series of eleven β‐santalol analogs, including nine new derivatives, was prepared by semisynthesis from natural (?)‐(Z)‐β‐santalol and studied by gas chromatography‐olfactometry (GC‐O) to characterize their olfactory properties and potencies. These compounds and 45 others selected in the literature were used to build three olfactophores by molecular modelling. Three models were obtained that gather structural and physicochemical constraints that will be useful for further design of new sandalwood odorants. |
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| Keywords: | Sandalwood β ‐Santalol Structure odor relationship (SOR) Olfactometry |
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