Cytotoxic Mannopyranosides of Indole Alkaloids from Zanthoxylum nitidum |
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| Authors: | Jiang Hu Xiaodong Shi Xia Mao Jiangang Chen Hui Li |
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| Affiliation: | 1. College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing 655011, P.?R. China, (phone/fax: +86‐874‐8998627);2. Institute of Characteristic Medicinal Resource of Ethnic Minorities, Qujing Normal University, Qujing 655011, P.?R. China;3. College of Physics and Electronic Engineering, Qujing Normal University, Qujing 655011, P.?R. China |
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| Abstract: | Three new mannopyranosides of indole alkaloids, methyl 7‐(β‐D ‐mannopyranosyloxy)‐1H‐indole‐2‐carboxylate ( 1 ), methyl 7‐[(3‐O‐acetyl‐β‐D ‐mannopyranosyl)oxy]‐1H‐indole‐2‐carboxylate ( 2 ), and 2‐methyl‐1H‐indol‐7‐yl β‐D ‐mannopyranoside ( 3 ), were isolated from an EtOH extract of the roots of Zanthoxylum nitidum. Their structures were identified as new compounds on the basis of the spectroscopic analyses. Bioactivity evaluation revealed that these alkaloids possess significant cytotoxicities against all the tested tumor cell lines with IC50 values of less than 30 μM . |
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| Keywords: | Zanthoxylum nitidum Indole alkaloids Alkaloids Mannopyranosides Cytotoxic activity |
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