Three New Phenylpropanoids from the Roots of Piper taiwanense and Their Inhibitory Activities on Platelet Aggregation and Mycobacterium tuberculosis |
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| Authors: | Si Chen Ming‐Jen Cheng Chin‐Chung Wu Chien‐Fang Peng Hung‐Yi Huang Hsun‐Shuo Chang Chyi‐Jia Wang Ih‐Sheng Chen |
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| Affiliation: | 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan (phone: +886‐7‐312‐1101 (ext 2191));2. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, TaiwanCorresponding authors for chemical aspects.First co‐author.;3. Department of Medical Laboratory Science and Biotechnology, College of Health Science, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan;4. Instrument Center, Center Resources, Research & Development (CRRD), Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan;5. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan (phone: +886‐7‐312‐1101 (ext 2191))Corresponding authors for chemical aspects.Corresponding author for general information. |
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| Abstract: | Bioassay‐guided fractionation of the active AcOEt‐soluble fraction from the roots of Piper taiwanense has led to the isolation of two new phenylpropanoids, taiwanensols A and B ( 1 and 2 , resp.), a new natural product, taiwanensol C ( 3 ), and 3‐acetoxy‐4‐hydroxy‐1‐allylbenzene ( 4 ). The compounds were obtained as two isomer mixtures ( 1 / 2 and 3 / 4 , resp.). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR spectroscopy and mass spectrometry, and by the comparison of their NMR data with those of related compounds. Compounds 1 – 4 were evaluated for their antiplatelet and antitubercular activities. The mixtures 1 / 2 and 3 / 4 showed potent inhibitory activities against platelet aggregation induced by collagen, with IC50 values of 35.2 and 8.8 μM , respectively. In addition, 1 / 2 and 3 / 4 showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.0 and 48.0 μg/ml, respectively. |
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| Keywords: | Piper taiwanense Taiwanensols A – C Phenylpropanoids Antiplatelet activity Antitubercular activity |
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