Cytotoxic Compounds from the Leaves of Garcinia polyantha |
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| Authors: | Alain Meli Lannang Simplice J N Tatsimo Hugues Fouotsa Jean Paul Dzoyem Ajit Kumar Saxena Norbert Sewald |
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| Institution: | 1. Department of Organic Chemistry, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon, (phone: +237‐77‐534830;2. fax: +237‐22‐229116);3. Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, P.O. Box 100131, D‐33501 Bielefeld;4. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;5. Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon;6. Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Jammu, India |
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| Abstract: | A new compound, named banganxanthone C (=12‐(1,1‐dimethylprop‐2‐en‐1‐yl)‐5,10‐dihydroxy‐9‐methoxy‐2‐methyl‐2‐(4‐methylpent‐3‐en‐1‐yl)‐2H,6H‐pyrano3,2‐b]xanthen‐6‐one; 4 ), together with five known compounds, were isolated from the leaves of Garcinia polyantha. The structures of the compounds were elucidated on the basis of 1D‐ and 2D‐NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol ( 2 ) and 4‐(2E)‐3,7‐dimethylocta‐2,6‐dien‐1‐yl]‐1,5,8‐trihydroxy‐3‐methoxy‐9H‐xanthen‐9‐one ( 3 ) exhibited significant antiproliferative activity against the leukemia cell line TPH‐1 with IC50 inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction. |
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| Keywords: | Garcinia polyantha Xanthones Antiproliferative activity |
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