Garcimultiflorone G,a Novel Benzoylphloroglucinol Derivative from Garcinia multiflora with Inhibitory Activity on Neutrophil Pro‐Inflammatory Responses |
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| Authors: | Chia‐Wei Ting Tsong‐Long Hwang Ih‐Sheng Chen Ming‐Jen Cheng Ping‐Jyun Sung Ming‐Hong Yen Jih‐Jung Chen |
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| Affiliation: | 1. Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;2. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Tao‐Yuan 333, Taiwan;3. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan;4. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan;5. Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan, (phone: +886‐8‐7624002 ext. 2827;6. fax: +886‐8‐7624002 ext. 5121) |
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| Abstract: | A novel benzoylphloroglucinol derivative, garcimultiflorone G ( 1 ), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D‐ and 2D‐NMR, and MS analyses. Garcimultiflorone G ( 1 ) showed inhibitory effects against superoxide anion (O$rm{{_{2}^{{^cdot} -}}}$ ) generation and elastase release by human neutrophils in response to formyl‐L ‐methionyl‐L ‐leucyl‐L ‐phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97±1.56 and 11.70±1.58 μM , respectively. |
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| Keywords: | Garcinia multiflora Garcimultiflorone G Biological activity |
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