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Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells |
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| Authors: | Plano Daniel Sanmartín Carmen Moreno Esther Prior Celia Calvo Alfonso Palop Juan Antonio |
| Institution: | aSección de Síntesis, Departamento de Química Orgánica y Farmacéutica, University of Navarra, Irunlarrea, 1, E-31008 Pamplona, Spain bOncology Division, Center for Applied Medical Research, CIMA, University of Navarra, Pío XII, 53, E-31008 Pamplona, Spain |
| Abstract: | A series of 17 symmetrical substituted imidothiocarbamate and imidoselenocarbamate derivatives has been synthesized by reacting appropriately substituted acyl chlorides with alkyl imidothiocarbamates and alkyl imidoselenocarbamates. The antitumoral activities of the compounds were evaluated in vitro by examining their cytotoxic effects against human prostate cancer cells (PC-3). Five compounds showed interesting activity levels and 3p (IC50 = 1.85 μM) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound. |
| Keywords: | Organoselenium Cytotoxics Prostate |
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