Effect of cyclosporin A treatment on renal calcium oxalate binding in experimental hyperoxaluria |
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Authors: | Adhirai Marimuthu Sakthivel Ramasamy Selvam Ramasamy |
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Affiliation: | (1) Department of Medical Biochemistry, Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India |
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Abstract: | This study was aimed to investigate the effect of Cyclosporin A administration on renal calcium oxalate binding under hyperoxaluric condition.Cyclosporin A administration or ammonium oxalate treatment increased calcium oxalate binding, which was further increased in kidney treated with cyclosporin A and ammonium oxalate together. The increase of calcium oxalate binding was associated with lipid peroxidation as well as with a concomitant decrease in total thiol in both rat and human kdiney homogenate.Cyclosporin A administration to hyperoxaluric rats resulted with increased calcium oxalate binding protein. However there was no change with specific activity of the protein.In conclusion, Cyclosporin A administration either to normal or hyperoxaluric rats is resulted with increased concentration of calcium oxalate binding protein as well as enhanced activity due to membrane lipid peroxidation. |
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Keywords: | cyclosporin A lipid peroxidation hyperoxaluria calcium oxalate binding |
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