从肠道微生物出发探讨其代谢产物与心血管疾病的关系

肠道菌群在维护人类的健康以及在疾病发展中起到重要的作用。随着对肠道菌群的逐步了解,人们发现肠道菌群结构和功能的紊乱与动脉粥样硬化和冠心病等心血管疾病的发生密切相关。肠道菌群的代谢产物例如氧化三甲胺、短链脂肪酸、胆汁酸和脂多糖的增多被认为是影响心血管疾病发生、发展和预后的危险因素。本文将阐述肠道菌群及其代谢产物在心血管疾病发病机制中的作用,从“心血管-肠道-肠道菌群”的角度,为心血管疾病的个体化辨证防治提供新的思路和方法。

Discussion on the relationship between intestinal microbial metabolites and cardiovascular system

Intestinal flora plays an important role in the maintenance of human health and disease development. With gradual understanding on intestinal flora, it has been found that the structural and functional disorders of intestinal flora are closely related to the occurrence of cardiovascular diseases such as atherosclerosis and coronary heart disease. The increase of metabolites of intestinal flora, such as trimetlylamine N oxide, short chain fatty acids, bile acids and lipopolysaccharide are considered as the risk factors affecting the occurrence, development and prognosis of cardiovascular diseases. This article will elaborate the role of intestinal flora and its metabolites in the pathogenesis of cardiovascular diseases, in order to provide new ideas and methods for individual differential prevention and treatment of cardiovascular diseases from the perspective of "cardiovascular intestinal intestinal flora".