复方嗜酸乳杆菌片联合乳果糖对糖尿病便秘患者脑肠肽水平的影响

目的 探讨复方嗜酸乳杆菌片联合乳果糖对糖尿病便秘患者脑肠肽水平的影响.方法 选择2018年1月-2019年8月在我院内科门诊治疗的糖尿病便秘患者92例,随机分为观察组和对照组各46例.两组均予建立良好生活习惯、饮食调整、适当运动、排便锻炼及药物控制血糖等基础治疗.对照组在此基础上加乳果糖口服液15 mL/次,2次/d,...

Effect of compound Lactobacillus acidophilus tablet combined with lactulose on brain and gut peptide levels in patients with diabetes

Objective To observe the effect of compound Lactobacillus acidophilus tablet combined with lactulose on brain and gut peptide levels in patients with diabetes. Methods Ninetytwo patients with diabetes and constipation who were treated in the outpatient department from January 2018 to August 2019 were randomly divided into observation group or control group, 46 cases each. Both groups were given the same basic treatments. The patients in control group were additionally given lactulose oral liquid, 15 mL bid, while those in observation group were given Lactobacillus acidophilus tablet, 1.0 g tid, for 12 weeks. The levels of serum braingut peptides [nitric oxide (NO), substance P (SP) and vasoactive intestinal peptide (VIP)] and constipation score were observed before and after treatment, and clinical effects were compared between groups. Results After treatment, the serum levels of NO, VIP and Wexner constipation scores in both groups were significantly lower, while that of SP was significantly higher (P2=4.040, P=0.046). Conclusion Compound Lactobacillus acidophilus tablet combined with lactulose is effective in treating patients with diabetes and constipation. Its mechanism of action may be improving colonic transmission through regulating brain and intestinal peptide secretion, reducing NO and VIP secretion, and promoting SP secretion.