肠道菌群在肥胖发病中的作用

近十年来,肠道菌群在人类许多疾病发病机制中的潜在作用引起了人们的广泛关注。已被证实肠道菌群与肥胖和肥胖相关的代谢性疾病的发生发展密切相关。与肥胖相关的肠道微生物可调控宿主的能量代谢、胰岛素抵抗和脂肪组织堆积,这些在肥胖发生中都起着至关重要的作用。本综述重点介绍了代谢紊乱中肠道菌群组成的变化以及肠道菌群在肥胖发病机制中的作用,包括能量代谢、中枢食欲、免疫系统和宿主昼夜节律。在不久的将来,该领域的研究将为治疗肥胖及其并发症开辟新的途径。

Role of intestinal microbiome in the pathogenesis of obesity

In the past decade, the potential role of intestinal microbiome in the etiology of various human diseases has attracted massive attention. As such, intestinal microbiota has been demonstrated to be an important contributor in the development of obesity and obesityrelated metabolic diseases. Obesityrelated gut microbes regulate host energy metabolism, insulin resistance and adipose tissue accumulation, all of which play a critical role in the development of obesity. The aim of this review is to describe the changes in the composition of intestinal microbiota that occur in obesity and the role of intestinal microbiota in the pathogenesis of several diseases such as obesity and metabolic syndrome, including energy metabolism, central appetite, host circadian rhythm and immune system. In the future, research in this field will set up a new way for the treatment of obesity and its complications.