Synthesis of the nuclear protein cyclin in growing, senescent and morphologically transformed human skin fibroblasts |
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Authors: | J E Celis R Bravo |
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Affiliation: | Division of Biostructural Chemistry, Department of Chemistry, Aarhus University, DK-8000, Denmark |
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Abstract: | Quantitative two-dimensional gel electrophoretic analysis (IEF) of the nuclear polypeptide cyclin in normal human skin biopsies, growing and senescent fibroblasts and morphologically transformed skin fibroblasts (limited life span) has revealed a direct correlation between the levels of this protein and proliferative state of the cells. These results strengthen the notion that cyclin may be a key component of the pathway(s) that control cell proliferation. |
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Keywords: | Transformation sensitive protein Cell proliferation Limited life span Two-dimensional gel electrophoresis IEF isoelectric focussing |
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