Atrial peptides induce mast cell histamine release. |
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Authors: | T J Opgenorth G P Budzik K W Mollison S K Davidsen M R Holst W H Holleman |
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Institution: | Abbott Laboratories, Abbott Park, IL 60064. |
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Abstract: | Human atrial natriuretic peptide ANF(1-28)] contains five arginine residues and carries an overall positive change of four. It was hypothesized that atrial peptides may induce mast cell histamine release. In vitro, three atrial peptides ANF(1-28), (3-28) and (5-28)] were demonstrated to induce dose-dependent histamine release from isolated rat peritoneal mast cells. In vivo, ANF(3-28) produced a dose-dependent increase in rat skin permeability which was blocked by antagonists of histamine and serotonin. The results indicate atrial peptides are capable of inducing mast cell degranulation in a manner similar to that described for other positively charged peptides. |
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