A model of the cerebellum in adaptive control of saccadic gain |
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Authors: | Nicolas Schweighofer Michael A Arbib Peter F Dominey |
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Institution: | (1) Center for Neural Engineering, University of Southern California, Los Angeles, CA 90089-2520, USA, US;(2) ATR Human Information Processing Research Laboratories, 2-2, Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-02, Japan, JP;(3) INSERM Unit 94, 16 ave du Doyen Lepine, F-69500 Bron, France, FR |
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Abstract: | We review data showing that the cerebellum is required for adaptation of saccadic gain to repeated presentations of dual-step
visual targets and thus, presumably, for providing adaptive corrections for the brainstem saccade generator in response to
any error created by the open-loop saccadic system. We model the adaptability of the system in terms of plasticity of synapses
from parallel fibers to Purkinje cells in cerebellar cortex, stressing the integration of cerebellar cortex and nuclei in
microzones as the units for correction of motor pattern generators. We propose a model of the inferior olive as an error detector,
and use a ‘window of eligibility’ to insure that error signals that elicit a corrective movement are used to adjust the original
movement, not the secondary movement. In a companion paper we simulate this large, realistic network of neural-like units
to study the complex spatiotemporal behavior of neuronal subpopulations implicated in the control and adaptation of saccades.
Received: 25 November 1994/Accepted in revised form: 6 February 1996 |
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