Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. |
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Authors: | Francis Karst and François Lacroute |
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Institution: | (1) Laboratoire de Génétique Physiologique, I.B.M.C. du C.N.R.S. Université Louis Pasteur, 15 rue Descartes, F-67084 Strasbourg Cedex, France |
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Abstract: | Summary Thermosensitive mutants, auxotrophic for ergosterol synthesis, have been isolated, analyzed genetically and their enzymatic deficiencies investigated. These mutants were classified into seven unlinked complementation groups. These groupes lack the following enzymatic activities: squalene epoxidase (erg 1), 2,3-oxidosqualene-lanosterol cyclase (erg 7), phosphomevalonic kinase (erg 8), mevalonic kinase (erg 12) and squalene synthetase (erg 9, erg 10, erg 11). |
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