妊娠期腹腔注射多氯联苯对大鼠性行为的影响

将50只同期怀孕的大鼠分为5组，在怀孕第7-18d，每天分别给两组大鼠腹腔注射1．00和20．00mg／kg体重2，2’，4，4’-四氯联苯（PCB47）；分别给另两组注射0．25和1．00mg／kg体重3，3’，4，4’-四氯联苯（PCB77）；对照组注射0．10mL芝麻油。幼鼠出生后第70-91d、97-101d测试F1代雌鼠的接近时间（AL）、爬跨后返回时间（MRL）、插入后返回时间（IRL）、射精后不应期（PER）、脊柱前凸系数（LQ）和雄鼠的爬跨频率（MF）、爬跨等待时间（ML）、插入频率（IF）、插入等待时间（IL）、射精等待时间（EL）、射精后不应期（PEI）、插入率等性行为。结果显示，妊娠期腹腔注射PCB47和PCB77显著降低F1代雌鼠的LQ（对照组为84．4％；PCB47组分别为76．0％、67．8％；PCB77组分别为64．4％、53．3％；P〉0．05），但对雌鼠的AL、MRL、IRL、PER和雄鼠的MF、ML、IF、IL、EL、PEI和插入率无显著影响（P〉0．05）。

Effects of Intraperitoneal Injection of Polychlorinated Biphenyls During Pregnancy on Sexual Behavior of F1 Rats

50 time-mated pregnant rats were divided into five groups and injected daily from gestational days 7 to 18 with either 2,2′,4,4′-tetrachlorobiphenyl (PCB 47) at the dosage of 1.00 or 20.00 mg/kg body weight;or 3,3′,4,4′-tetrachlorobiphenyl (PCB 77) at the dosage of 0.25 or 1.00 mg/kg body weight;or sesame oil (control) to investigate the effects of fetal and lactational PCB exposure on reproductive behavior in male and female laboratory rats. Offspring were then tested for male sexual behavior: mount frequency, MF;mount latency, ML;intromission frequency, IF;intromission latency, IL;ejaculation latency, EL;post ejaculatory interval, PEI;hit rate and female sexual behavior;approach latency, AL;mount return latency, MRL;intromission return latency, IRL;post ejaculatory refractory period, PER;lordosis quotient, LQ. Measures were made at the age of postnatal days 70 to 91, and 97 to 101, respectively. The results showed that exposure to both PCB 77 and PCB 47 significantly reduced the LQ (84.4% for control, 76.0%, 67.8% for PCB 47 groups and 64.4%, 53.3% for PCB 77 groups;P<0.05) in the female offspring. There were no significant effects on AL, MR, IRL, PER (P>0.05) of the female offspring, or on MF, ML, IF, IL, EL, PEI and hit rate (P>0.05) of the male offspring.