Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China |
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Authors: | Qiwei Zhang Donald Seto Bin Cao Suhui Zhao Chengsong Wan |
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Institution: | aDepartment of Microbiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China;bSchool of Systems Biology, George Mason University, Manassas, Virginia, USA;cDepartment of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University;dBeijing Institute of Respiratory Medicine;eBeijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing, China |
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Abstract: | Human adenovirus type 55 (HAdV-B55) is an acute respiratory disease (ARD) pathogen first completely characterized in China (2006). This is a unique Trojan horse microbe with the virus neutralization attribute of a renal pathogen and the cell tropism and clinical attributes of a respiratory pathogen, bypassing herd immunity. It appeared to be an uncommon pathogen, with earlier putative, sporadic occurrences in Spain (1969) and Turkey (2004); these isolates were incompletely characterized using only two epitopes. Reported here is the genome of a second recent isolate (China, 2011), indicating that it may occur more frequently. The availability of this HAdV-B55 genome provides a foundation for studying adenovirus molecular evolution, the dynamics of epidemics, and patterns of pathogen emergence and re-emergence. These data facilitate studies to predict genome recombination between adenoviruses, as well as sequence divergence rates and hotspots, all of which are important for vaccine development and because HAdVs are used for epitope and/or gene delivery vectors. |
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