Zinc Finger Antiviral Protein Inhibits Murine Gammaherpesvirus 68 M2 Expression and Regulates Viral Latency in Cultured Cells |
| |
| Authors: | Yifang Xuan Ling Liu Sheng Shen Hongyu Deng Guangxia Gao |
| |
| Affiliation: | aCAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Chaogang District, Beijing, China;bGraduate School of Chinese Academy of Sciences, Beijing, China;cCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China |
| |
| Abstract: | Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to specific viral mRNAs and repressing mRNA expression. Here we report that ZAP inhibits expression of murine gammaherpesvirus 68 (MHV-68) M2, which plays important roles in establishment and maintenance of viral latency. Downregulation of endogenous ZAP in cells harboring latent MHV-68 promoted lytic replication of the virus. These results suggest that ZAP inhibits M2 expression and regulates the maintenance of MHV-68 latency. |
| |
| Keywords: | |
|
|
