Ivermectin Inhibits Growth of Chlamydia trachomatis in Epithelial Cells |
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| Authors: | Matthew A Pettengill Verissa W Lam Ikechukwu Ollawa Camila Marques-da-Silva David M Ojcius |
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| Institution: | 1. Molecular Cell Biology, Health Sciences Research Institute, University of California Merced, Merced, California, United States of America.; 2. Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America.; 3. Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; University Paris Sud, France, |
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| Abstract: | Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia. |
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