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The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor |
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| Authors: | DeNinno Michael P Masamune Hiroko Chenard Lois K DiRico Kenneth J Eller Cynthia Etienne John B Tickner Jeanene E Kennedy Scott P Knight Delvin R Kong Jimmy Oleynek Joseph J Tracey W Ross Hill Roger J |
| Institution: | Pfizer Global Research and Development, Groton/NewLondon Laboratories, Groton, CT 06340, USA. michael.p.deninno@pfizer.com |
| Abstract: | Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups. |
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