| 阳离子聚合物在非病毒基因转染中的研究进展 |
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| 引用本文： | 任先越,杨立群,梁玄,刘珍珍,邓宇斌.阳离子聚合物在非病毒基因转染中的研究进展[J].生物工程学报,2013,29(5):568-577. |
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| 作者姓名： | 任先越 杨立群 梁玄 刘珍珍 邓宇斌 |
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| 作者单位： | 1. 中山大学附属第一医院转化医学中心实验室,广东广州 510080;中山大学中山医学院病理生理学教研室,广东广州510080
2. 中山大学化学与化学工程学院高分子研究所 聚合物复合材料及功能材料教育部重点实验室 新型聚合物材料设计合成与应用广东省高校重点实验室,广东广州,510275 |
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| 基金项目： | 广东省科技计划项目 (Nos. 2009B020313001, 201213091100457) 资助。 |
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| 摘 要： | 基因治疗为治疗先天性遗传疾病和严重后天获得性疾病提供了一条新途径.目前,基因载体分为两类:病毒载体和非病毒载体.病毒载体转染效率高,但由于某些病毒载体存在免疫原性、致癌性、宿主DNA插入整合等缺点,从而限制了它们的应用.非病毒载体具有价格低、制备简单、安全有效、无免疫原性等优点,成为基因载体研究的热点.阳离子多聚物是非病毒载体的典型代表.文中综述近年来阳离子多聚物作为基因载体的研究现状和进展,重点介绍了阳离子多聚物基因载体的分类和与DNA的相互作用和传递机制.
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| 关 键 词： | 基因治疗 非病毒载体 阳离子聚合物 |
| 收稿时间： | 2012/11/19 0:00:00 |
Advances in cationic polymers used as nonviral vectors for gene delivery |
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| Xianyue Ren,Liqun Yang,Xuan Liang,Zhenzhen Liu and Yubin Deng.Advances in cationic polymers used as nonviral vectors for gene delivery[J].Chinese Journal of Biotechnology,2013,29(5):568-577. |
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| Authors: | Xianyue Ren Liqun Yang Xuan Liang Zhenzhen Liu and Yubin Deng |
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| Institution: | 1 Laboratory of Research Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China; 2 Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China;3 Key Laboratory of Designed Synthesis and Application of Polymer Material, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, Guangdong, China;3 Key Laboratory of Designed Synthesis and Application of Polymer Material, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, Guangdong, China;3 Key Laboratory of Designed Synthesis and Application of Polymer Material, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, Guangdong, China;1 Laboratory of Research Center for Translational Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong, China; 2 Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, Guangdong, China |
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| Abstract: | Gene therapy has been considered as a promising method for treatment of many diseases, such as acquired and genetic diseases. At present, there are two major vehicles for gene delivery including viral vectors and nonviral vectors. Viral vectors appear as high gene transfection efficiency, but some deficiencies such as inflammatory responses, recombination and mutagenesis have limited their use. On account of low pathogenicity, safety and cost-effectiveness, nonviral vectors have been attracted much attention. Cationic polymers are one of the nonviral vectors which have been widely studied. This review focuses on the structure of the cationic polymers and the interaction mechanism between the vector and DNA. We try to provide a framework for the future design and synthesis of nonviral vectors with high transfection efficiency and low toxicity for gene therapy. |
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| Keywords: | gene therapy nonviral vectors cationic polymer |
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