Age-dependent characteristics of immune cytolysis of mouse cells with cytogenetic changes induced by streptolysin O

It has been determined that streptolysin-O induces cytogenetic alterations in the cell culture of murine kidneys in all the mice examined, the most pronounced alterations being noted in the cells of newborn and, especially, old mice. The injection of syngeneic lymphocytes from newborn and sexually mature mice of the middle age group has led to a considerable decrease in the number of cells with altered chromosome number in cultures. The lymphocytes from old mice have no antimutagenic activity.