A strategy to study <Emphasis Type="Italic">tyrosinase</Emphasis> transgenes in mouse melanocytes |
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Authors: | Alfonso?Lavado Ander?Matheu Manuel?Serrano Email author" target="_blank">Lluís?MontoliuEmail author |
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Institution: | Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB-CSIC), Campus de Cantoblanco, C/ Darwin, 3 28049 Madrid, Spain. Alfonso.Lavado@STJUDE.ORG |
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Abstract: | Background A number of transgenic mice carrying different deletions in the Locus Control Region (LCR) of the mouse tyrosinase (Tyr) gene have been developed and analysed in our laboratory. We require melanocytes from these mice, to further study, at the
cellular level, the effect of these deletions on the expression of the Tyr transgene, without potential interference with or from the endogenous Tyr alleles. It has been previously reported that it is possible to obtain and immortalise melanocyte cell cultures from postnatal
mouse skin. |
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