Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat. |
| |
| Authors: | J E Jalil R Ebensperger J Meléndez E Acevedo M Sapag-Hagar F González-Jara A Gálvez V Pérez-Montes S Lavandero |
| |
| Affiliation: | Department of Cardiovascular Diseases, School of Medicine, P. Catholic University of Chile, Santiago. |
| |
| Abstract: | There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and alpha-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drugs in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, alpha-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat. |
| |
| Keywords: | |
|
|
