Sensitivity and specificity amplification in signal transduction |
| |
Authors: | Li Guangpu Qian Hong |
| |
Institution: | (1) Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, 73104 Oklahoma City, OK;(2) Department of Applied Mathematics, University of Washington, 98195 Seattle, WA |
| |
Abstract: | Intracellular signal transduction pathways transmit signals from the cell surface to various intracellular destinations, such
as cytoskeleton and nucleus through a cascade of protein-protein interactions and activation events, leading to phenotypic
changes such as cell proliferation, differentiation, and death. Over the past two decades, numerous signaling proteins and
signal transduction pathways have been discovered and characterized. There are two major classes of signaling proteins: phosphoproteins
(e.g., mitogen-activated protein kinases) and guanosine triphosphatases (GTPases; e.g., Ras and G proteins). They both function
as molecular switches by addition and removal of one or more high-energy phosphate groups. This review discusses developments
that seek to quantify the signal transduction processes with kinetic analysis and mathematical modeling of the signaling phosphoproteins
and GTPases. These studies have provided insights into the sensitivity and specificity amplification of biological signals
in integrated systems. |
| |
Keywords: | Signal transduction phosphorylation kinase phosphatase MAPK GTP hydrolysis GTPase G protein Ras kinetics mathematical modeling |
本文献已被 PubMed SpringerLink 等数据库收录! |
|