Inhibition of fatty acid synthesis by RMI 14,514 (5-tetradecyloxy-2-furoic acid) |
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Authors: | T Kariya L J Wille |
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Affiliation: | Biochemistry Department, Merrell-National Laboratories, Division of Richardson-Merrell Inc. Cincinnati, Ohio 45215 USA |
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Abstract: | RMI 14,514 strongly inhibited the incorporation of label from [1-14C]acetyl-CoA into fatty acids by rat liver homogenates. No inhibition was observed when [2-14C]malonyl-CoA was used as the labeled fatty acid precursor. These results suggest that the drug inhibits fatty acid biosynthesis at the step mediated by acetyl-CoA carboxylase. The data presented in this communication support earlier reports that RMI 14,514 probablyexerts its hypolipidemic effects by inhibition of fatty acid biosynthesis. |
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