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| 血管紧张素转换酶2-血管紧张素1-7-Mas轴对血管作用的研究进展 | |
| 作者姓名： | Liu CQ Huang Y Lu LM |
| 作者单位： | 1. 复旦大学上海医学院生理学与病理生理学系,上海,200032;杭州师范学院生理学教研室,杭州,310018 2. 复旦大学上海医学院生理学与病理生理学系,上海,200032;香港中文大学医学院生理学系,香港新界沙田 3. 复旦大学上海医学院生理学与病理生理学系,上海,200032 |
| 摘 要： | 血管紧张素转换酶2（ACE2）和Mas受体的发现使人们对肾素-血管紧张素（RAS）有了更全面的认识。ACE2可水解血管紧张素Ⅰ和血管紧张素Ⅱ直接或间接生成血管紧张素1-7（Ang 1-7）,并与高血压的形成密切相关。Ang 1-7主要通过Mas受体引起血管舒张、抑制细胞增殖。ACE2-Ang1-7-Mas轴的发现为RAS的研究、高血压等心血管疾病的防治和新药开发提供了新的思路和方向。 |
| 关 键 词： | 血管紧张素转换酶2 血管紧张素1-7 血管紧张素1-7受体 肾素-血管紧张素系统 |
Effects of ACE2-Ang 1-7-Mas axis on blood vessel |
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| Liu CQ,Huang Y,Lu LM.Effects of ACE2-Ang 1-7-Mas axis on blood vessel[J].Progress in Physiological Sciences,2007,38(1):43-48. | |
| Authors: | Liu Cui-Qing Huang Yu Lu Li-Min |
| Institution: | Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China. |
| Abstract: | The recent identification of angiotensin-converting enzyme 2 (ACE2) and Mas receptor opened new recognition of renin-angiotensin system (RAS). ACE2, a homologue of angiotensin-converting enzyme (ACE) generates angiotensin 1-7 directly through cleaving angiotensin II, or indirectly through angiotensin I in the body. Ang 1-7 exhibits vasodilatory and antiproliferative effects, and these effects were mainly mediated by Mas receptor. So ACE2-angiotensin1-7- Mas axis was considered a negative regulation in renin angiotensin system (RAS), and its significance has been implicated into hypertension and other cardiovascular diseases. The identification of the axis opens a new potential venue for further study and understanding of RAS. |
| Keywords: | Zangiotensin-converting enzyme 2 angiotensin 1-7 angiotensin 1-7 receptor renin-angiotensin system |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |