Chromosome banding and compaction |
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| Authors: | A Leth Bak A Lund Jørgensen J Zeuthen |
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| Institution: | (1) Institute of Medical Microbiology, University of Aarhus, The Bartholin Building, DK-8000 Aarhus C, Denmark;(2) Institute of Human Genetics, University of Aarhus, The Bartholin Building, DK-8000 Aarhus C., Denmark |
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| Abstract: | Summary We have described a characteristic substructure of mitotic chromosomes, the chromosomal unit fibre, with lengths about five times the length of the corresponding metaphase chromosomes and a uniform diameter of 0.4  m. In order to study the relationship of chromosome banding to chromosome compaction, methods have been devised to obtain banding patterns on chromosomal unit fibres, similar to G-band patterns of intact mitotic chromosomes. The total number of bands plus interbands per haploid human karyotype is estimated at about 3000. The banding pattern of chromosomal unit fibres indicates a certain resemblance to the normal G-banding pattern of human chromosomes even if the details indicate a short-range random distribution. |
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