Luteinizing hormone induces expression of 11beta-hydroxysteroid dehydrogenase type 2 in rat Leydig cells |
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| Authors: | Qian Wang Ping Zhang Hui-Bao Gao |
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| Affiliation: | (1) Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chong Qing Road, Shanghai, 200025, PR China;(2) Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 280 South Chong Qing Road, Shanghai, 200025, PR China |
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| Abstract: | Background Leydig cells are the primary source of testosterone in male vertebrates. The biosynthesis of testosterone in Leydig cells is strictly dependent on luteinizing hormone (LH). On the other hand, it can be directly inhibited by excessive glucocorticoid (Corticosterone, CORT, in rats) which is beyond the protective capability of 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and type 2 (11beta-HSD2; encoded by gene Hsd11b2 in rats) in Leydig cells. Our previous study found that LH increases 11beta-HSD1 expression in rat Leydig cells, but the effect of LH on the expression and activity of 11beta-HSD2 is not investigated yet. |
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