Expression of P23 of Cryptosporidium parvum in Toxoplasma gondii and evaluation of its protective effects |
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| Authors: | Shirafuji Hiroaki Xuan Xuenan Kimata Isao Takashima Yasuhiro Fukumoto Shinya Otsuka Haruki Nagasawa Hideyuki Suzuki Hiroshi |
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| Institution: | National Research Center for Protozoan Disease, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokaido, Japan. |
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| Abstract: | In this study, P23 of Cryptosporidium parvum sporozoites, an immunodominant surface protein, was stably expressed in Toxoplasma gondii (Tg/P23) and its protective effects were evaluated in a mouse model. The molecular weight and antigenic property of P23 expressed by Tg/P23 were similar to those of the native P23. Mice immunized with lysed Tg/P23 tachyzoites produced specific neutralizing antibodies against C. parvum. These findings indicate that the T. gondii vector may provide a new tool for the production of a recombinant vaccine against cryptosporidiosis in animals. |
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