Inhibition of prostaglandin synthesis in man |
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Authors: | Mats Hamberg |
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Institution: | Department of Chemistry, Karolinska Institutet, Stockholm, Sweden |
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Abstract: | 7α-Hydroxy-5,11-diketotetranor-prostane-1,16-dioic acid, the major urinary metabolite of prostaglandins E1 and E2 in man, was determined in human urine by a method based on the use of the bis (O-2H3-methyloxime) derivative of dimethyl 7α-hydroxy-5,11-diketotetranor-prostane-1,16-dioate as internal standard and determination of the ratio between unlabeled and deuterium-labeled molecules by multiple-ion analysis. Male subjects excreted larger amounts of the metabolite (6.5–46.7 μg/24 hours, n=10) than did female subjects (2.5–5.3 μg/24 hours, n=10). The excretion rate was strongly suppressed following oral administration of therapeutic doses of indomethacin, aspirin and sodium salicylate. |
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