Stimulation of “nude” spleen cells in vitro under the influence of thymus lymphocytes |
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| Authors: | Rita Bö sing-SchneiderBerenice Kindred |
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| Affiliation: | Immunology Unit, Division of Biology, University of Konstanz, Constance, Germany |
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| Abstract: | Spleen cells from “nude” mice (nu/nu) were stimulated in vitro with sheep erythrocytes. After 4 days of in vitro incubation only a few plaque-forming cells were found in these cultures. This immunological deficit can be restored by adding thymus lymphocytes from allogeneic donors to nu/nu spleen cultures. The restoration is not successful when thymocytes are prevented from proliferating, by irradiation or with Mitomycin C, or when their DNA dependent RNA synthesis is suppressed by actinomycin D. |
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