| CTLA-4基因微卫星多态性与粤西汉族人Graves病的相关性研究 |
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| 引用本文： | 陈晓铭,郭中秋,周飞,吴美芬,武革.CTLA-4基因微卫星多态性与粤西汉族人Graves病的相关性研究[J].现代生物医学进展,2010,10(8). |
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| 作者姓名： | 陈晓铭 郭中秋 周飞 吴美芬 武革 |
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| 摘 要： | 目的:探讨细胞毒性T淋巴细胞相关抗原-4(cytotoxie T lymphocyte associated antigen-4,CTLA-4)基因微卫星多态性CTLA-4(AT)n]与湛江沿海地区汉族人Graves病(GD)的相关性.方法:收取2006年门诊及住院患者中确诊为Graves病(Craves' disease,GD)102例和正常对照组100例,应用聚合酶链式反应-单链长度多态性分析法(PCR-SSLP)确定CTLA-4基因第4外显子3'末端AT重复序列的基因型.结果:CTLA-4基因3'末端微卫星位点有20个等位基因,GD组与正常对照组之间之间的基因频率差异无统计学意义(P>0.05).结论:CTLA-4(AT)n多态性可能与GD无相关性.
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| 关 键 词： | 细胞毒性T淋巴细胞相关抗原 基因多态性 Graves 病 遗传 |
Correlation between Gene Polymorphism of Cytotoxic T Lymphocyte Associated Antigen-4 and Graves Disease in Han People in the West of Guangdong |
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| CHEN Xiao-ming,GUO Zhong-qiu,ZHOU Fei,WU Mei-fen,WU Ge.Correlation between Gene Polymorphism of Cytotoxic T Lymphocyte Associated Antigen-4 and Graves Disease in Han People in the West of Guangdong[J].Progress in Modern Biomedicine,2010,10(8). |
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| Authors: | CHEN Xiao-ming GUO Zhong-qiu ZHOU Fei WU Mei-fen WU Ge |
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