| 新型雌激素受体ER-α36与乳腺癌 |
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| 引用本文： | 廉馨 史丹 李洪艳. 新型雌激素受体ER-α36与乳腺癌[J]. 中国生物化学与分子生物学报, 2015, 31(1): 34-37. DOI: 10.13865/j.cnki.cjbmb.2015.01.06 |
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| 作者姓名： | 廉馨 史丹 李洪艳 |
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| 基金项目： | 国家自然科学基金项目( No. 30970353)， 辽宁省教育厅重点实验室项目（No.LS2010095） |
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| 摘 要： | 雌激素受体(estrogen receptor,ER)是诊断和治疗乳腺癌的分子标志和靶点.雌激素受体包括ER-α和ER-β,其中ER-α有ER-α66、ER-α46和ER-α36三种亚型.ER-α36作为新型雌激素受体,参与膜起始的雌激素信号或非基因组雌激素信号转导,在肿瘤细胞的增殖、分化、侵袭和转移等过程中发挥作用.胃癌、子宫内膜腺癌、前列腺癌、尤其是乳腺癌的发生发展与ER-α36密切相关.本文介绍了ER-α36的结构域特点,ER-α36介导的信号通路及ER-α36在乳腺癌治疗中的作用研究进展.
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| 关 键 词： | 雌激素受体 雌激素受体α36 乳腺癌 |
| 收稿时间： | 2014-04-03 |
ER-α36 and Breast Cancer |
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| LIAN Xin SHI Dan LI Hong-Yan. ER-α36 and Breast Cancer[J]. Chinese Journal of Biochemistry and Molecular Biology, 2015, 31(1): 34-37. DOI: 10.13865/j.cnki.cjbmb.2015.01.06 |
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| Authors: | LIAN Xin SHI Dan LI Hong-Yan |
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| Abstract: | Estrogen receptor (ER) expression is an important prognostic and predictive factor in breast cancer. Estrogen receptors include ER-α and ER-β. There are three subtypes in ER-α, including ER-α66，ER-α46 and ER-α36. ER-α36, which is a novel isoform of human estrogen receptor, mediating non-genomic or membrane-initiated signaling pathway. ER-α36 plays a role in tumor cell proliferation, differentiation,invasion and metastasis. ER-α36 is closely related to gastric cancer, endometrial adenocarcinoma, prostate cancer, and especially the breast cancer occurrence anddevelopment. In this paper, we introduce the structural features, signaling pathways of ER-α36 and the role of ER-α36 in the treatment of breast cancer. |
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| Keywords: | estrogen receptor ER-α36 breast cancer |
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