线粒体功能障碍与孤独症

孤独症谱系障碍（ASDs）患儿中约有5%伴有线粒体功能紊乱.线粒体功能紊乱会损害对能量高度依赖的生理进程，如神经发育和神经可塑性，从而导致孤独症.本文综述了孤独症个体中线粒体过量的活性氧（reactive oxygen species，ROS）产生及其抗氧化系统减弱、呼吸链复合物异常、线粒体基因突变及与线粒体功能相关的基因组DNA编码的蛋白质异常等方面的研究，旨在阐述线粒体系统多方面的紊乱在孤独症个体中均有所体现，希望能够对孤独症的发病机制和治疗提供帮助.

Mitochondrial Dysfunction in Autism

Approximately 5% of children with autism spectrum disorders (ASDs) are associated with mitochondrial dysfunction. Mitochondrial dysfunction could impair highly energy dependent physiological processes such as neurodevelopment and plasticity, thereby contributing to autism. In this paper, we summarized the recent studies on mitochondrial increased reactive oxygen species production and poor cellular antioxidant system, malfunction of mitochondrial respiratory chain complexes, mutations in the mitochondrial DNA, and abnormality of proteins essential for mitochondrial functions are encoded by the genomic DNA in autistic disorder, hoping that it would be helpful for the pathogenesis and therapy of autism.