Human pluripotent stem cells for disease modelling and drug screening |
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Authors: | Maury Yves Gauthier Morgane Peschanski Marc Martinat Cécile |
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Affiliation: | CECS, ISTEM, AFM, Evry Cedex, France. |
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Abstract: | Considerable hope surrounds the use of disease-specific pluripotent stem cells to generate models of human disease allowing exploration of pathological mechanisms and search for new treatments. Disease-specific human embryonic stem cells were the first to provide a useful source for studying certain disease states. The recent demonstration that human somatic cells, derived from readily accessible tissue such as skin or blood, can be converted to embryonic-like induced pluripotent stem cells (hiPSCs) has opened new perspectives for modelling and understanding a larger number of human pathologies. In this review, we examine the opportunities and challenges for the use of disease-specific pluripotent stem cells in disease modelling and drug screening. Progress in these areas will substantially accelerate effective application of disease-specific human pluripotent stem cells for drug screening. |
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Keywords: | drug screening human embryonic stem cells monogenic diseases human induced pluripotent stem cells pathological modelling |
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