Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23 |
| |
Authors: | Smith T S Southan C |
| |
Affiliation: | Department of Molecular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA. |
| |
Abstract: | We have identified human and mouse cDNAs encoding a novel ubiquitin-specific protease designated USP23. Both cDNAs encode a 62-kDa protein containing the highly conserved His and Cys domains characteristic of the C19 cysteine protease family of ubiquitin-specific processing proteases (UCH-2). Human tissue Northern blots revealed USP23 to be ubiquitously expressed, whereas USP12, its closest human paralogue, displayed a more restricted expression pattern. The human USP23 gene mapped to chromosome 1q22. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|