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Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies |
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| Authors: | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock |
| Affiliation: | 1.Signal Transduction, Cancer Research UK London Research Institute, 44 Lincoln''s Inn Fields, London WC2A 3LY, UK;2.Bioinformatics and Biostatistics, Cancer Research UK London Research Institute, 44 Lincoln''s Inn Fields, London WC2A 3LY, UK;3.High Throughput Screening Laboratories, Cancer Research UK London Research Institute, 44 Lincoln''s Inn Fields, London WC2A 3LY, UK |
| Abstract: | |
| Keywords: | KRAS synthetic lethal oncogene addiction proteasome topoisomerase |