Hypothalamic activity during altered salt and water balance in the snake <Emphasis Type="Italic">Bothrops jararaca</Emphasis> |
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Authors: | Leonardo Zambotti-Villela Camila Eduardo Marinho Rafaela Fadoni Alponti Paulo Flavio Silveira |
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Institution: | 1.Laboratory of Pharmacology,Instituto Butantan,S?o Paulo,Brazil |
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Abstract: | The effects of water and salt overload on the activities of the supraoptic and paraventricular nuclei and the adjacent periventricular
zone of the hypothalamus of the snake Bothrops jararaca were investigated by measurements of Fos-like immunoreactivity (Fos-ir). Both water and salt overload resulted in changes
in body mass, plasma osmolality, and plasma concentrations of sodium, potassium, and chloride. Hyper-osmolality increased
Fos immunoreactivity in the rostral supraoptic nucleus (SON), the paraventricular nucleus (PVN), and adjacent periventricular
areas. Both hyper- and hypo-osmolality increased Fos immunoreactivity in the intermediate SON, but not in other areas of the
hypothalamus. Immunostaining was abundant in cerebrospinal fluid (CSF)-contacting tanycyte-like cells in the ependymal layer
of the third ventricle. These data highlight some features of regional distribution of Fos immunoreactivity that are consistent
with vasotocin functioning as a hormone, and support the role of hypothalamic structures in the response to disruption of
salt and water balance in this snake. |
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Keywords: | Fos Body fluid and electrolyte homeostasis Hypothalamus Supraoptic nucleus Paraventricular nucleus CSF-contacting cells |
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