Association of cardiolipin and cytochrome oxidase |
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| Authors: | Y C Awasthi T F Chuang T W Keenan F L Crane |
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| Affiliation: | 1. Department of Biological Sciences Purdue University, Lafayette, Indiana 47907 USA;2. Department of Animal Science Purdue University, Lafayette, Indiana 47907 USA |
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| Abstract: | A small amount of cardiolipin (diphosphatidyl glycerol) is tightly bound to cytochrome oxidase. The stoichiometry approaches one molecule of cardiolipin per molecule of cytochrome a. Solvent extraction and phospholipase treatments which remove or destroy other phospholipids and the bulk cardiolipin do not effect this tightly bound cardiolipin. Potential oxidase activity and membrane formation potential are lost when the tightly bound cardiolipin is removed. This cardiolipin is very similar in fatty acid composition to the total mitochondrial cardiolipin. |
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