| 氧化修饰HDL剌激培养人主动脉平滑肌细胞增殖 |
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| 引用本文： | 江渝,刘秉文.氧化修饰HDL剌激培养人主动脉平滑肌细胞增殖[J].生物化学与生物物理进展,1999,26(6):606-608. |
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| 作者姓名： | 江渝 刘秉文 |
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| 作者单位： | 华西医科大学载脂蛋白研究室，成都 610041;华西医科大学载脂蛋白研究室，成都 610041 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金及美国纽约中华医学基金部分资助. |
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| 摘 要： | 平滑肌细胞（smooth muscle cell, SMC）增殖在动脉粥样硬化（atherosclerosis, AS）形成中起着重要作用.氧化修饰HDL（oxidized HDL, OX-HDL）可刺激 3H-TdR掺入培养人动脉SMC的DNA，促进SMC增殖.以四甲基偶氮唑盐(MTT)法直接观察OX-HDL对培养人动脉SMC增殖细胞数的影响.结果显示，天然HDL（native HDL N-HDL）对SMC增殖没有影响，而OX-HDL则显著刺激SMC增殖（P＜0.01），N-HDL显著抑制OX-LDL刺激SMC增殖作用（P＜0.01），而OX-HDL则显著增加OX-LDL刺激SMC增殖作用（P＜0.01）
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| 关 键 词： | 高密度脂蛋白，氧化修饰，平滑肌细胞 增殖 |
| 收稿时间： | 1998/10/28 0:00:00 |
| 修稿时间： | 3/2/1999 12:00:00 AM |
Effect of Oxidized High Density Lipoproteins on Proliferation of Cultured Human Arterial Smooth Muscle Cells |
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| JIANG Yu and LIU Bing-Wen.Effect of Oxidized High Density Lipoproteins on Proliferation of Cultured Human Arterial Smooth Muscle Cells[J].Progress In Biochemistry and Biophysics,1999,26(6):606-608. |
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| Authors: | JIANG Yu and LIU Bing-Wen |
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| Institution: | Apolipoprotein Research Unit, Institute of Biochemistry and Molecular Biology, West China University of Medical Sciences, Chengdu 610041, China;Apolipoprotein Research Unit, Institute of Biochemistry and Molecular Biology, West China University of Medical Sciences, Chengdu 610041, China |
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| Abstract: | The proliferation of arterial SMC plays an important role in process of atherosclerosis. Oxidized HDL(OX HDL) can increase 3H TdR incorporation to DNA of cultured human arterial SMC, so promote proliferation of SMC. A study on effect of OX HDL on proliferation of cultured human arterial SMC with MTT method was made. It was showed that native HDL(N HDL) has no effect on proliferation of SMC but OX HDL significantly stimulated the proliferation of SMC ( P <0 01);N HDL significantly inhibited proliferation of human SMC induced by OX LDL ( P <0 01) and OX HDL significantly enhanced proliferation of human SMC induced by OX LDL ( P <0 01). |
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| Keywords: | high density lipoprotein oxidative modification smooth muscle cell proliferation |
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