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24-nor-5β-chol-22-enes derived from the major bile acids by oxidative decarboxylation |
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| Authors: | Gerald L. Carlson Don T.E. Belobaba Alan F. Hofmann Yuri Wedmid |
| Affiliation: | Gastroenterology Unit, Mayo Clinic and Foundation, Rochester, MN 55901, USA The Hormel Institute, University of Minnesota, Austin, MN 55912, USA |
| Abstract: | The preparation of 24-nor-5β-chol-22-enes from formyloxy-5β-cholanic acids by oxidative decarboxylation with lead tetraacetate is described. NMR data is presented with other physical constants for the norcholenes derived from cholic, chenodeoxycholic, ursodeoxycholic, hyodeoxycholic, and deoxycholic acids. The facile synthesis of these norcholenes demonstrates the applicability of the formyloxy protecting group to oxidative decarboxylations in the bile acid series. |
| Keywords: | Send reprint requests to: Dr. John G. Wagner Upjohn Center for Clinical Pharmacology The University of Michigan Ann Arbor Michigan 48109. |
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